TY  - BOOK
AU  - Shargel,Leon
AU  - Yu,Andrew B.C.
TI  - Applied biopharmaceutics & pharmacokinetics
SN  - 97898131500508 (Pbk. : NP)
AV  - RM301.4 .A67 2016
U1  - 615.7 23
PY  - 2016///
CY  - New York
PB  - McGraw-Hill Education
KW  - Biopharmaceutics
KW  - Pharmacokinetics
KW  - Drug Administration Routes
KW  - Models, Chemical
N1  - Includes bibliographical references and index; Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis
ER  -