Cardiotonic activity of croton ( Codiaeum variegatum) crude leaf extract on guinea pigs Fenelyn T. Lagundi, Jonathan C. Lim and Mae Rosario P. Soberano

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ABSTRACT Lagundi, Fevelyn T., Lim, Jonathan C., Soberano, Mae Rosario P. Undergraduate Thesis. Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, City of Batac 2906, Ilocos Norte, March 2010. Cardiotonic activity of croton (Codiaeum variegatum) crude Adviser: Augustus Caesar C. Pati A pharmacologic investigation was undertaken to determine the cardiotonic activity of Croton (Codiaeum variegatum) crude leaf xtract on guinea pigs (Cavia porcellus). Confirmatory test for the presence of cardiac glycoside was conducted and confirmed using Keller-Killani Test, Leibermann-Buchard Test, Bate-Smith Test and Metcalf test, and kedde test. Cardiotonic activity of croton crude leaf extract (CCLE) was tested on test animals and as a reference, Digoxin (Lanoxin) was used asa positive control and Plain Normal Saline Solution (PNSS) for the negative control. There were three concentration of CCLE used in the study. The concentrations are 50%, 75% and 100%. Based on the findings of the study, the researcheds had found out that Croton (Codiaeum variegatum) crude leaf extract contains cardiac glycosides. The plant crude leaf extract has a positive inotropic effect as a cardiotonic activity which increases the hearts force of contraction. There is a significant difference of cardiotonic activity between treatments used in the study.