Hypocholesterolemic Property of the Isolated Tannins Obtained from Siam Weed (Chromolaena Adorata Asteracea) Leaf Extract on Guinea Pigs / JOyce L. Gervacio., Aple Joy M. Herrera, Randolf C. Padayao
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TextPublication details: 2010Description: xi, 55 leaves 28 cmSummary: ABSTRACT GERVACIO, JOYCE L., HERRERA, APLE JOY M., PADAYAO, RANDOLF C., Undergraduate Thesis. Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, City of Batac 2906, Ilocos Norte, HYPOCHOLESTEROLEMIC PROPERTY OF THE ISOLATED TANNINS OBTAINED FROM SIAM WEED (CHROMOLAENA ADORATA ASTERACEA) LEAF EXTRACT ON GUINEA PIGS. Adviser: Rhian Jaymar D. Ramil This research utilized a descriptive - experimental study on the property of the isolated tannins obtained from Siam Weed (Chromolaena odorata, Asteraceae) leaf extract as blood cholesterol lowering agent. The air-dried sample of Siam Weed (Chromolaena odorata, Asteraceae) was extracted through maceration and the tannin contents were isolated for testing. Its cholesterol lowering activity was tested on fifteen (15) guinea pigs that were randomly selected to represent three (3) groups: a) Negative control group which were treated with distilled water, b) Positive control group which received the standard drug Simvastatin, and c) Test control group treated with isolated tannins obtained from Siam Weed (Chromolaena odorata, Asteraceae) leaf extract. Boiled quail eggs and cholesterol powder (400mg/kg body weight), however, were used to induce hypercholesterolemia to the test animals. The data obtained were treated using Mean and Standard Deviation as descriptive statistics on the blood cholesterol level of the guinea pigs. The study was laid in Analysis of Variance (ANOVA) to test if there exist significant difference among the treatments mean. To determine which treatment means are significantly different from each other, the Least Significant Difference (LSD) test was used. Based from the data gathered, isolated tannins obtained from Siam Weed (Chromolaena odorata, Asteraceae) leaf extract are capable of lowering the blood cholesterol level on cholesterol induced-guinea pigs, thus, they are as effective as the standard drug, Simvastatin.
| Item type | Home library | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| Thesis/Dissertation | MMSU College of Health Sciences | 94-Pharm (Browse shelf(Opens below)) | Available |
Thesis (BS Pharmacy) - Mariano Marcos State University - College of Health Sciences, City of Batac
Bibliography; 38 – 39 leaves
ABSTRACT GERVACIO, JOYCE L., HERRERA, APLE JOY M., PADAYAO, RANDOLF C., Undergraduate Thesis. Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, City of Batac 2906, Ilocos Norte, HYPOCHOLESTEROLEMIC PROPERTY OF THE ISOLATED TANNINS OBTAINED FROM SIAM WEED (CHROMOLAENA ADORATA ASTERACEA) LEAF EXTRACT ON GUINEA PIGS. Adviser: Rhian Jaymar D. Ramil This research utilized a descriptive - experimental study on the property of the isolated tannins obtained from Siam Weed (Chromolaena odorata, Asteraceae) leaf extract as blood cholesterol lowering agent. The air-dried sample of Siam Weed (Chromolaena odorata, Asteraceae) was extracted through maceration and the tannin contents were isolated for testing. Its cholesterol lowering activity was tested on fifteen (15) guinea pigs that were randomly selected to represent three (3) groups: a) Negative control group which were treated with distilled water, b) Positive control group which received the standard drug Simvastatin, and c) Test control group treated with isolated tannins obtained from Siam Weed (Chromolaena odorata, Asteraceae) leaf extract. Boiled quail eggs and cholesterol powder (400mg/kg body weight), however, were used to induce hypercholesterolemia to the test animals. The data obtained were treated using Mean and Standard Deviation as descriptive statistics on the blood cholesterol level of the guinea pigs. The study was laid in Analysis of Variance (ANOVA) to test if there exist significant difference among the treatments mean. To determine which treatment means are significantly different from each other, the Least Significant Difference (LSD) test was used. Based from the data gathered, isolated tannins obtained from Siam Weed (Chromolaena odorata, Asteraceae) leaf extract are capable of lowering the blood cholesterol level on cholesterol induced-guinea pigs, thus, they are as effective as the standard drug, Simvastatin.
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