Hepatoprotective Property of Glycoside Obtained From the Roots of Parangis (Elesine Indica, Poaceae) / Marichou C. Domingo, Nestor C. Pasion Jr., Anna Jaybin F.

Thesis (BS Pharmacy) - Mariano Marcos State University - College of Health Sciences, City of Batac

Bibliography; 43 – 45 leaves

ABSTRACT DOMINGO, MARICHOU C., PASION JR., NESTOR C., TINGUIL, ANNA JAYBIN F., Undergraduate Thesis. Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, City of Batac 2906, Ilocos Norte, March 2010. HEPATOPROTECTIVE PROPERTY OF GLYCOSIDE OBTAINED FROM THE ROOTS OF PARANGIS (Elesine Indica, Poaceae) Adviser: Imelda B. Corpuz
A variety of herbal plants are abundant in the country that inspire people to find alternative ways to achieve beneficial remedy for illnesses. This is the reason why many studies are conducted by researchers to discover a safe yet effective natural product. Parangis is one of the many herbal plants which is very abundant in the locality and is being used diuretic, anthelminthic, and treatment for dysentery. This study investigates the hepatoprotective properly of glycosides obtained from the roots of Parangis (Elesine Indica). Ten mg/kg and five mg/kg were used as a sample dose in glycosides and were compared with the standard drug (Silymarin). Paracetamol was used to induce-hepatotoxicity in albino rats. The parameters assessed were liver weights of test animals as well as the change in body weights. Serum Level of Glumatic Pyruvate Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT) were also determined. The experimental research design was employed to gather data that can prove the hepatoprotective property of glycosides. It was observed from the examination of live weights that Paracetamol intoxicated animals resulted in increased weight that pertains to liver enlargement while glycosides 10 mg/kg and Silymarin have no significant difference on the weights of the liver. Change in body weights were observed among the five treatment group which showed highly significant results. The SGOT levels of the animals among the five treatment group showed significant differences on the weights of the liver. Change in body weights were observed among the five treatment group which showed highly significant results. The SGOT levels of the animals among the five treatment group showed significant differences and a significant increase in SGPT was seen in Paracetamol-intoxicated animals. It was found out that glycosides at a dose of 10 mg/kg gave a better effect than a dose of 5,g/kg with regards to SGPT Level.