Acio, Eloisa Mae N., et al.  <br/><br/>
Anti-Emetic Property of Paragis (Eleusine Indica L.) Leaf and Stem Extract in Copper Suifate Pentahydrate-Induced Bullfrogs (Pana Joponica) / 
Eloisa Mae N. Acio, Bibiana Christian Mae B. Coloma, Mary Grace P. Juan, and Shella Marie P. Sabado 
 - October 2007 
 - viii, 53 leaves.  28 cm. 
<br/><br/> Theses/Dissertations (BS Pharmacy) -Mariano Marcos State University 
<br/><br/> ABSTRACT  ACIO, ELOISA MAE N., COLOMA, BIBIANA CHRISTIAN MAE B., JUAN, MARY GRACE P., SABADO, SHELLA MARIE P. Undergraduate thesis. Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, Batac City 2906 Ilocos Norte, October 2007. ANTI-EMETIC PROPERTY OF PARAGIS (ELEUSINE INDICA L.) LEAF AND STEM EXTRACT IN COPPER SUIFATE PENTAHYDRATE-INDUCED BULLFROGS (PANA JOPONICA). 53 pp Thesis Adviser: Mr. Rhian Jaymar D. Ramil  A scientific investigation was done to examine the anti-emetic effect of Paragis (Eleusine indica L.) leaf and stem extract on bullfrogs and to determine the phytochemical substances present in the leaf stem extract. Anti-emetic effect was tested on the animals and Metoclopramide HCL was used as a positive control and 5% Sorbitol as the negative control. The leaf and stem extract was subjected to a ptyochemical screening test. The use of Liebermann-Burchard test indicated the presence of saponins specifically triterpenes and was confirmed using froth, capillary and hemolytic test. Administration of different size of doses (500mg/kg body weight, 1000mg/kg body weight) were used to determine the effective dose that will manifest an anti-emetic effect of the plant. As a parameter, emetic latency was measured from the experimental animals. The leaf and stem extract of Eleusive indica L. showed a significant difference in preventive vomiting of the copper sulfate-induced bullfrogs compared to positive control (Metoclopramide HCl).