000			02720nam a22001817a 4500
003			OSt
005			20220221135432.0
008			220106b |||||||| |||| 00| 0 eng d
040			_aMMSU _bULS _cULS
100			_aLeonador, Axel Carlo J., Ramajo, Ina Feliza and Sibulao, Sarra Shayne T.
245			_aAnthulithiatic activity of calamansi (Citrus microcarpa Bunge) juice on ethylene glycol-induced nephrolithiasis in male guinea pigs _cAxel Carlo J. Leonador, Ina Feliza A. Ramajo and Sarra Shayne T. Sibulao
260			_c2010
300			_ax, 59 leaves _b28 cm.
500			_aThesis (BS Pharmacy), Mariano Marcos State University-College of Health Sciences, City of Batac
504			_aBibliography; 37 – 38 leaves
520			_aABSTRACT _bLEONARDOR, AXEL CARLO J., RAMAJO, INA FELIZE A., SIBULAO, SARRA SHAYNE T. Undergraduate Thesis. Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, City of Batac 2906, Ilocos Norte, March 2010. ANTILITHIATIC ACTIVITY OF CALAMANSI (Citrus microcarpa Bunge) JUICE ON ETHYLENE GLYCOL-INDUCED NEPHROLITHIASIS IN MALE GUINEA PIGS Adviser. Kristian Gay Y. Dutdut The study was conducted to determine the antilithiatic activity of calamansi (Citrus microcarpa Bunge) juice. The effectiveness of the juice to lower creatinine and uric acid levels was compared to a standard drug and distilled water. This study used ethylene glycol induced hyperoxaluria model in male guinea pigs to test the antilithiatic activity of the different concentrations (25%, 50%, 75%, 100%) of Calamansi (Citrus microcarpa Bunge) juice and to determine which concentration exhibited the best results. Results of the study revealed that the different concentrations of Calamansi (Citrus microcarpa Bunge) juice can lower both creatinine and uric acid levels of thet test animals. Of all the treatment concentrations, the 50% treatment concentration showed the best effect in lowering creatinine levels while the 25% treatment concentration showed the best effect in lowering uric acid levels. Moreover, based on the results gathered, the Calamansi (Citrus microcarpa Bunge) juice exhibited better antilithiatic activity than that of the commercial drug (potassium citrate). The Calamansi (Citrus microcarpa Bunge) juice can be attributed to the presence of citric acid. Oral intake of citric acid boots levels of citrate in the urine and reduce the crystallization of uric acid and calcium oxalate – the most frequently found ingredient in kidney stones. Based on the results, the researchers therefore conclude that the juice obtaines from the Calamansi (Citrus microcarpa Bunge) fruit is an effective alternative treatment for nephrolithiasis.
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999			_c17044 _d17044