000			02679nam a22001817a 4500
003			OSt
005			20220309105143.0
008			220309b |||||||| |||| 00| 0 eng d
040			_aMMSU _bULS _cULS
100			_aAvisado, Jasmin M., Mangapit, Myra P., Ortega, Geniel M.
245			_aBlood Glucose Lowering Activity Of Eel Grass (Enhalus Acoroides) Leaf Extract In Alloxan-Induced Hyperglycemic Rats / _cJasmin M. Avisado., Myra P. Mangapit., Geniel M. Ortega
260			_cMarch 2014
300			_ax, 74 leaves _b28 cm.
500			_aThesis (Bachelor of Science in Pharmacy) -- Mariano Marcos State University - College of Health Sciences, Batac City
504			_aBibliography: leaves 40-43
520			_aABSTRACT _bAVISADO, J.M., MANGAPIT, M.O., ORTEGA, G.M. ., Mariano Marcos State University, College of Health Sciences, Department of Pharmacy, City of Batac 2906, Ilocos Norte. MARCH 2014. Blood Glucose Lowering Activity Of Eel Grass (Enhalus Acoroides) Leaf Extract In Alloxan-Induced Hyperglycemic Rats. Adviser: Prof. Janelyn V. Rojas. This study used a pretest-postetst design to determine the antihyperglycemic activity of Eel Grass (Enhalus Acoroides) Leaf Extract. Moreover, it aimed to identify the phytochemicals present and to assess the safety for administration to the test animals. The leaves were extracted through maceration and were subjected to rotary evaporation. The antihyperglycemic assay involved 15 albino rats grouped into five ; group I received normal saline at 5 mL/kg., group II served as the hyperglycemic control, group II received Gilbenclamide at 5mL/kg, group IV and V were treated orally with the leaf extract at doses 1000mg/kg and 2000 mg/kg. hyperglycemia was induced using alloxan at a dose of 100mg/kg. blood glucose was monitored after 2, 4, and 6 hours of administration of treatment. The data gathered were statistically analyzed using the t-test for independent samples. Based on the results, there is no significant difference between Glibenclamide and the leaf extract at doses 1000mg/kg and 2000 mg/kg. Therefore, the antihyperglycemic activity of the leaf extract is comparable to the standard drug and the leaf extract possesses effective blood glucose lowering activity. The phytochemical screening revealed that the leaf extract contains alkaloids and polyphenols that are responsible for its blood glucose lowering activity. Oral cute toxicity test was performed using the Organisation for Economic Cooperation and Development (OECD) guideline. Observation was done for a total of 14 days where none of the dosed test animals died which means that the leaf extract is safe and nontoxic.
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